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Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

19 Jan 2018

Abstract excerpt

p53 is a transcription factor that is implicated in the control of both apoptotic and autophagic cell death. This tumor suppressor elicits both pro-autophagic and anti-autophagic phenotypes depending of its intracellular localization. The ability of p53 to repress autophagy has been exclusively associated to its cytoplasmic localization. Here, we show that transcriptional activity of p53 also contributes to...

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PMID: 29352272
DOI: 10.1038/s41418-017-0016-0

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