Article

Interferon regulatory factor 3 upregulates the Treg recruitment factor CCL22 in response to double-stranded DNA in cancer cells

2022-03-10

Abstract excerpt

Cancer immunotherapy holds great promise for the treatment of solid tumors, but its effectiveness is hindered by the recruitment of regulatory T cells (Tregs), which inhibit anti-tumor immune responses. We report here that cytosolic dsDNA, a characteristic of many cancer cells, upregulates expression of the Treg-recruitment chemokine CCL22 in multiple types of malignant epithelial cells. We also identified that in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6c5346e-5f41-5a92-bdab-912e11300192
DOI: 10.1101/2022.03.08.483519

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interferon regulatory factor 3 upregulates the Treg recruitment factor CCL22 in response to double-stranded DNA in cancer cellsDOI 10.1101/2022.03.08.483519Read

The Cytosolic DNA-Sensing cGAS–STING Pathway in CancerSemantic proximity Read

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer ImmunotherapiesSemantic proximity Read

DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment RemodelingSemantic proximity Read

Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunitySemantic proximity Read

Activation of Stimulator of Interferon Genes (STING): Promising Strategy to Overcome Immune Resistance in Prostate CancerSemantic proximity Read

STING Promotes Breast Cancer Cell Survival by an Inflammatory-Independent Nuclear Pathway Enhancing the DNA Damage ResponseSemantic proximity Read

Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic PotentialSemantic proximity Read

Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathwaySemantic proximity Read

Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effectSemantic proximity Read

STING pathway agonism as a cancer therapeuticSemantic proximity Read

The STING in the Tail for Cytosolic DNA–Dependent Activation of IRF3Semantic proximity Read

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of CancerSemantic proximity Read