Article

CCR4 blockade leads to clinical activity and prolongs survival in a canine model of advanced prostate cancer

2021-04-12

Abstract excerpt

Targeting regulatory T cell (Treg) infiltration is an emerging strategy for cancer immunotherapy. However, the efficacy of this strategy in advanced prostate cancer remains unclear. Here, we describe the therapeutic efficacy of this strategy in a canine model of advanced prostate cancer. We used dogs with naturally occurring prostate cancer to study the molecular mechanism underlying Treg infiltration into tumor t...

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Literature Corpus work: b6a89661-30af-5136-8f24-70c773f74b3f
DOI: 10.1101/2021.04.12.439476

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