Article
BRAFV595E Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs.
Veterinary pathology - 1 Sept 2021
Maeda Shingo, Yoshitake Ryohei, Chambers James K, Uchida Kazuyuki, Eto Shotaro, Ikeda Namiko, Nakagawa Takayuki, Nishimura Ryohei, Goto-Koshino Yuko, Yonezawa Tomohiro, Momoi Yasuyuki
Abstract excerpt
Regulatory T cells may serve as targets in cancer immunotherapy. A previous study showed that the chemokine CCL17 and the receptor CCR4 play roles in regulatory T cell recruitment in canine urothelial carcinoma. In this article, we show that the BRAFV595E mutation is associated with tumor-produced CCL17 and regulatory T cell infiltration in dogs with urothelial carcinoma. In comparison with healthy dogs, dogs...
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