Article

Somatic Mutations in <i>MCOLN3</i> in Aldosterone-Producing Adenomas cause Primary Aldosteronism

2024-10-23

Abstract excerpt

Primary aldosteronism is characterized by renin-independent hyperaldosteronism that originates from aldosterone-producing lesions in the adrenal glands. Under physiological conditions, aldosterone synthase ( CYP11B2 ) expression is confined to the adrenal zona glomerulosa where it catalyzes the final reaction yielding aldosterone. The regulation of CYP11B2 transcription depends on the control of cellular membran...

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Literature Corpus work: b6a7f38c-6f47-53a4-8728-1b038e87bfb2
DOI: 10.1101/2024.10.20.619295

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