Article

Recurrent Viral Capture of Cellular Phosphodiesterases that Antagonize OAS-RNase L

2023-05-14

Abstract excerpt

Phosphodiesterases (PDEs) encoded by viruses are putatively acquired by horizontal transfer of cellular PDE ancestor genes. Viral PDEs inhibit the OAS-RNase L antiviral pathway, a key effector component of the innate immune response. Although the function of these proteins is well-characterized, the origins of these gene acquisitions is less clear. Phylogenetic analysis revealed at least five independent PDE acqui...

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Literature Corpus work: b6939774-04fa-5b60-b17f-b605707fd921
DOI: 10.1101/2023.05.12.540623

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