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Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L

26 Jan 2024

Abstract excerpt

Phosphodiesterases (PDEs) encoded by viruses are putatively acquired by horizontal transfer of cellular PDE ancestor genes. Viral PDEs inhibit the OAS-RNase L antiviral pathway, a key effector component of the innate immune response. Although the function of these proteins is well-characterized, the origins of these gene acquisitions are less clear. Phylogenetic analysis revealed at least five independent PDE...

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PMID: 38277437
DOI: 10.1073/pnas.2312691121

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