Article
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2010
Ching Michael S L, Shen Yiping, Tan Wen-Hann, Jeste Shafali S, Morrow Eric M, Chen Xiaoli, Mukaddes Nahit M, Yoo Seung-Yun, Hanson Ellen, Hundley Rachel, Austin Christina, Becker Ronald E, Berry Gerard T, Driscoll Katherine, Engle Elizabeth C, Friedman Sandra, Gusella James F, Hisama Fuki M, Irons Mira B, Lafiosca Tina, LeClair Elaine, Miller David T, Neessen Michael, Picker Jonathan D, Rappaport Leonard, Rooney Cynthia M, Sarco Dean P, Stoler Joan M, Walsh Christopher A, Wolff Robert R, Zhang Ting, Nasir Ramzi H, Wu Bai-Lin
Abstract excerpt
Research has implicated mutations in the gene for neurexin-1 (NRXN1) in a variety of conditions including autism, schizophrenia, and nicotine dependence. To our knowledge, there have been no published reports describing the breadth of the phenotype associated with mutations in NRXN1. We present a medical record review of subjects with deletions involving exonic sequences of NRXN1. We ascertained cases from 3,540...
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