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Article

A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens

2019-01-13

Abstract excerpt

<h4>Background</h4> Chemicals in disparate structural classes activate specific subsets of PPARγ’s transcriptional programs to generate adipocytes with distinct phenotypes. <h4>Objectives</h4> Our objectives were to 1) establish a novel classification method to predict PPARγ ligands and modifying chemicals, and 2) create a taxonomy to group chemicals based on their effects on PPARγ’s transcriptome and downstream...

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Literature Corpus work
b6248df0-56e5-5d49-89df-79393ca0fb08
DOI
10.1101/519629
Open publication

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A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite AdipogensDOI 10.1101/519629
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