Article

Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response

2018-06-12

Abstract excerpt

Glioblastoma (GBM) is often resistant to conventional and targeted therapeutics. ERBB4 is expressed throughout normal brain and is an oncogene in several pediatric brain cancers; therefore, we investigated ERBB4 as a prognostic marker and therapeutic target in GBM. Using RT-qPCR, we quantified mRNA encoding total ERBB4 and known ERBB4 variants in GBM and non-neoplastic normal brain (NNB) samples. Using immunohisto...

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Literature Corpus work: b621f3b0-4a07-5eed-8aa6-a88eaf87518f
DOI: 10.20944/preprints201806.0197.v1

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