Article

Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell models

2022-05-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Glioblastoma is characterized by hyperactivation of kinase signaling pathways. Regardless, most glioblastoma clinical trials targeting kinase signaling have failed. We hypothesized that overcoming the glioblastoma kinase inhibitor tolerance requires efficient shut-down of phosphorylation-dependent signaling rewiring by simultaneous inhibition of multiple critical kinases com...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b60b0d95-36e2-5b3a-8464-1c1e29ff7321
DOI: 10.1101/2022.05.31.494146

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pharmacological PP2A reactivation overcomes multikinase inhibitor tolerance across brain tumor cell modelsDOI 10.1101/2022.05.31.494146Read

PP2A ‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cellsSemantic proximity Read

Monotherapy efficacy of BBB-permeable small molecule activators of PP2A in glioblastomaSemantic proximity Read

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.Semantic proximity Read

Characterization of prevalent tyrosine kinase inhibitors and their challenges in glioblastoma treatmentSemantic proximity Read

Development of Actionable Targets of Multi-kinase Inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cellsSemantic proximity Read

Adaptive Kinase Signalling Enables Escape from Small Molecule Inhibition in GlioblastomaSemantic proximity Read

Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergismsSemantic proximity Read

EGFR upregulation drives signaling reactivation during EGFR inhibition in glioblastoma without broad kinome rewiringSemantic proximity Read

Tyrosine phosphoproteome profiling identifies cell-intrinsic signals limiting the efficacy of tyrosine kinase inhibitor therapiesSemantic proximity Read

Brain-Restricted mTOR Inhibition with Binary PharmacologySemantic proximity Read

Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertibSemantic proximity Read

Brain-Restricted mTOR Inhibition with Binary PharmacologySemantic proximity Read