Article

Inflammation-Linked Aging Signals in Frozen Single-Cell Foundation Models: Donor-Aware Detection and Robustness Testing

2026-04-13

Abstract excerpt

<title>Abstract</title> <p>Single-cell foundation models offer a possible route to studying aging biology in latent space, but apparent age effects can be distorted by donor identity and cell-composition differences. We developed a donor-aware interpretability workflow to test whether frozen scGPT and Geneformer representations contain biologically coherent aging signals in age-labeled human single-cell datasets....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5f1b0f3-09c3-5e86-97e5-1f60aeed2894
DOI: 10.21203/rs.3.rs-9289672/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inflammation-Linked Aging Signals in Frozen Single-Cell Foundation Models: Donor-Aware Detection and Robustness TestingDOI 10.21203/rs.3.rs-9289672/v1Read

Decoding Conserved and Tissue-Specific Cellular Stress Programs from Single-Cell Foundation Models Using Sparse AutoencodersSemantic proximity Read

An inflammatory gene set–driven epigenetic clock tracks down disease progression and rejuvenationSemantic proximity Read

Programmatic Adaptive Failure in Myeloid Cells: A Novel Mechanism Linking Frailty to Accelerated Epigenetic AgingSemantic proximity Read

Interpretable Aging Signatures in Human Retinal Cell Types Revealed by Single-Cell RNA Sequencing and Sparse Logistic RegressionSemantic proximity Read

Phenotypic reversion and target prioritization for cellular inflammation via representation learning with foundation modelsSemantic proximity Read

A generator-matrix causal-inference framework separates measurable aging biomarkers from mortality-driving latent dynamics in humansSemantic proximity Read

Characterizing Cellular Heterogeneity and Transcriptomic Features of Senotype Using Deep Graph Representation LearningSemantic proximity Read

Histological aging signatures enable tissue-specific disease prediction from bloodSemantic proximity Read

EpInflammAge: Epigenetic-Inflammatory Clock for Disease-Associated Biological Aging Based on Deep LearningSemantic proximity Read

TRAILBLAZER: generative multicellular perturbation model of biologySemantic proximity Read

Transcriptomic age prediction using mixture-of-experts models reveals tissue-specific aging signatures in large-scale human RNA-sequencing dataSemantic proximity Read

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging.Semantic proximity Read