Article

Interpretable Aging Signatures in Human Retinal Cell Types Revealed by Single-Cell RNA Sequencing and Sparse Logistic Regression

2025-06-01

Abstract excerpt

<h4>Purpose</h4> To characterize cell type specific transcriptional changes during human retinal aging and develop machine learning model for cellular age discrimination in a Chinese cohort. <h4>Design</h4> Cross-sectional, laboratory-based observational study. <h4>Participants</h4> Eighteen unfrozen retinas from 12 Chinese donors (9 young, 34-55y; 9 old, 68-92 y). <h4>Methods</h4> Single-cell RNA sequencing (...

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Literature Corpus work: 3ccd4276-652c-5bda-856b-f774986cfa52
DOI: 10.1101/2025.05.29.656930

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