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Article

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging.

PloS one - 1 Jan 2015

Whiting Chan C, Siebert Janet, Newman Aaron M, Du Hong-Wu, Alizadeh Ash A, Goronzy Jorg, Weyand Cornelia M, Krishnan Eswar, Fathman C Garrison, Maecker Holden T

Abstract excerpt

While many age-associated immune changes have been reported, a comprehensive set of metrics of immune aging is lacking. Here we report data from 243 healthy adults aged 40-97, for whom we measured clinical and functional parameters, serum cytokines, cytokines and gene expression in stimulated and unstimulated PBMC, PBMC phenotypes, and cytokine-stimulated pSTAT signaling in whole blood. Although highly...

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Identifiers

PMID: 26197454
DOI: 10.1371/journal.pone.0133627
PMCID: PMC4509650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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