Article

ProAffinity-GNN: A Novel Approach to Structure-based Protein-Protein Binding Affinity Prediction via a Curated Dataset and Graph Neural Networks

2024-03-15

Abstract excerpt

Protein-protein interactions (PPIs) are crucial for understanding biological processes and disease mechanisms, contributing significantly to advances in protein engineering and drug discovery. The accurate determination of binding affinities, essential for decoding PPIs, faces challenges due to the substantial time and financial costs involved in experimental and theoretical methods. This situation underscores the...

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Literature Corpus work: b5c9048d-5574-5d51-a0ad-3645a25268a2
DOI: 10.1101/2024.03.14.584935

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