Article

Reversal of Disease Phenotypes in ALS and Genetic Premature Aging Cells by Redirecting Misfolded TDP-43 Proteins into Physiological TDP-43 Oligomers

2023-10-17

Abstract excerpt

A group of misfolded prone-to-aggregate domains in disease-causing proteins has recently been shown to adopt unique conformations that play a role in fundamental biological processes, including the formation of membrane-less sub-organelles, alternative splicing, and gene activation. The cellular responses are regulated by the conformational switching of prone-to-aggregate domains. Given this, targeting the misfold...

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Literature Corpus work: b57f9a0b-162a-5ffe-bb86-54b1e394b831
DOI: 10.21203/rs.3.rs-3341543/v1

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