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Targeting TDP‐43 proteinopathy with drugs and drug‐like small molecules

29 May 2020

Abstract excerpt

Following the discovery of the involvement of the ribonucleoprotein TDP-43 in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), a major research focus has been to develop treatments that can prevent or alleviate these disease conditions. One pharmacological approach has been to use TDP-43-based disease models to test small molecules and drugs already known to have some therapeutic...

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PMID: 32469420
DOI: 10.1111/bph.15148

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