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Article

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases.

Nature cell biology - 1 Nov 2004

Selkoe Dennis J

Abstract excerpt

The salutary intersection of fundamental cell biology with the study of disease is well illustrated by the emerging elucidation of neurodegenerative disorders. Novel mechanisms in cell biology have been uncovered through disease-orientated research; for example, the discovery of presenilin as an intramembrane aspartyl protease that processes many diverse proteins within the lipid bilayer. A common theme has...

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PMID: 15516999
DOI: 10.1038/ncb1104-1054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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