Article

FAM111A regulates replication origin activation and cell fitness

2020-04-23

Abstract excerpt

<h4>ABSTRACT</h4> FAM111A is a replisome associated protein and dominant mutations within its trypsin-like peptidase domain are linked to severe human developmental syndromes. However, FAM111A functions and its putative substrates remain largely unknown. Here, we showed that FAM111A promotes origin activation and interacts with the putative peptidase FAM111B, and we identified the first potential FAM111A substrat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b57bf628-b3a7-5bab-af5c-d7e7f2140be2
DOI: 10.1101/2020.04.22.055574

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FAM111A regulates replication origin activation and cell fitnessDOI 10.1101/2020.04.22.055574Read

FAM111A regulates replication origin activation and cell fitnessSemantic proximity Read

FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease.Semantic proximity Read

Gain-of-function mutations amplify cytotoxic FAM111 protease activity in human genetic disordersSemantic proximity Read

Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications.Semantic proximity Read

Functions and evolution of FAM111 serine proteasesSemantic proximity Read

Congenital Diseases of DNA Replication: Clinical Phenotypes and Molecular Mechanisms.Semantic proximity Read

Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases.Semantic proximity Read

PRIM1 deficiency causes a distinctive primordial dwarfism syndrome.Semantic proximity Read

FAM111A protects replication forks from protein obstacles via its trypsin-like domain.Semantic proximity Read

Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range PhenotypeSemantic proximity Read

Cooption of polyalanine tract into a repressor domain in the mammalian transcription factor HoxA11Semantic proximity Read

Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complexSemantic proximity Read