Article

The POLR3A/ARG2/spermine axis drives tamoxifen resistance in breast cancer

2026-07-25

Abstract excerpt

<title>Abstract</title> <p>Tamoxifen resistance remains a significant therapeutic challenge in estrogen receptor-positive (ERα+) breast cancer. Although arginine metabolic reprogramming has been recognized as a driver of tumor progression, its role in tamoxifen resistance is not well understood. In this study, we demonstrate that the arginine-metabolizing enzyme ARG2 and its metabolite spermine are significantly...

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Literature Corpus work: b57b5126-f10b-5f70-a966-b7c7a390cb16
DOI: 10.21203/rs.3.rs-8322190/v1

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