Article
Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor.
Nature communications - 15 Apr 2021
Zou Zizheng, Hu Xiyuan, Luo Tiao, Ming Zhengnan, Chen Xiaodan, Xia Li, Luo Wensong, Li Jijia, Xu Na, Chen Ling, Cao Dongsheng, Wen Min, Kong Fanrong, Peng Kunjian, Xie Yuanzhu, Li Xuan, Ma Dayou, Yang Chuanyu, Chen Ceshi, Yi Wenjun, Liu Ousheng, Liu Suyou, Luo Junli, Luo Zhiyong
Abstract excerpt
Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate. ASS1 genetic deficiency in patients leads to an autosomal recessive urea cycle disorder citrullinemia, while its somatic silence or down-regulation is very common in various human cancers. Here, we show that ASS1 functions as a tumor suppressor in breast cancer, and...
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