Article

Activation of Toll-like receptor 2 via specific agonists promotes OXPHOS and glycolysis in gastric cancer cells rather than other Toll-like receptors

2020-12-08

Abstract excerpt

<h4>Background: </h4> Toll-like receptor (TLR)2 activation via microbial and host stimuli plays important roles in the regulation of metabolic reprogramming in immune cells. We recently showed that ligand-induced TLR2 activation enhanced OXPHOS and glycolytic activity of gastric epithelial (cancer) cells, thus promoting tumour progression. Objective To investigate the full spectrum of TLR family members whose lig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b55f37dc-7a95-52c4-a4cd-d360716bd712
DOI: 10.21203/rs.3.rs-115816/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of Toll-like receptor 2 via specific agonists promotes OXPHOS and glycolysis in gastric cancer cells rather than other Toll-like receptorsDOI 10.21203/rs.3.rs-115816/v1Read

Metabolic Reprogramming Across Molecular Subtypes of Gastric CancerSemantic proximity Read

Gastric cancer cells shuttle lactate to induce inflammatory CAF-like phenotype and function in bone marrow-derived mesenchymal stem cells.Semantic proximity Read

Enterococcus faecalis Infection Causes Inflammation, Intracellular Oxphos-Independent ROS Production, and DNA Damage in Human Gastric Cancer CellsSemantic proximity Read

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancySemantic proximity Read

Glycolytic side pathways regulating macrophage inflammatory phenotypes and functions.Semantic proximity Read

Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylationSemantic proximity Read

Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated ImmunopathologySemantic proximity Read

A Comprehensive High-Efficiency Protocol for Isolation, Culture, Polarization, and Glycolytic Characterization of Bone Marrow-Derived Macrophages.Semantic proximity Read

Glutathionylation of Pyruvate Dehydrogenase Complex E2 and Inflammatory Cytokine Production During Acute Inflammation Are Magnified By Mitochondrial Oxidative StressSemantic proximity Read

Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway inductionSemantic proximity Read

Metabolic Reprogramming in Response to Alterations of Mitochondrial DNA and Mitochondrial Dysfunction in Gastric AdenocarcinomaSemantic proximity Read

Analyzing the Metabolic Phenotype of Bone Marrow-Derived Dendritic Cells by Assessing Their Oxygen Consumption and Extracellular Acidification.Semantic proximity Read