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Insights into the Mechanism of Ethionamide Resistance in <em>Mycobacterium tuberculosis</em> through an <em>in silico</em> Structural Evaluation of EthA and Mutants Identified in Clinical Isolates

2020-03-31

Abstract excerpt

Mutation in the ethionamide (ETH) activating enzyme, EthA, is the main factor determining resistance to this drug, used to treat TB patients infected with MDR and XDR Mycobacterium tuberculosis isolates. Many mutations in EthA of ETH resistant (ETH-R) isolates have been described but their roles in resistance remain uncharacterized, partly because structural studies on the enzyme are lacking. Thus, we took a two-t...

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Literature Corpus work
cb5aef71-1823-543f-90f5-6e2e44d015cc
DOI
10.20944/preprints202003.0470.v1
Open publication

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Insights into the Mechanism of Ethionamide Resistance in <em>Mycobacterium tuberculosis</em> through an <em>in silico</em> Structural Evaluation of EthA and Mutants Identified in Clinical IsolatesDOI 10.20944/preprints202003.0470.v1
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