Article

Epigenome Editing Durability Varies Widely Across Cardiovascular Disease Target Genes

2023-05-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hepatic knockdown of the proprotein convertase subtilisin/kexin type 9 ( PCSK9 ) gene or the angiopoietin-like 3 ( ANGPTL3 ) gene has been demonstrated to reduce blood low-density lipoprotein cholesterol (LDL-C) levels, and hepatic knockdown of the angiotensinogen ( AGT ) gene has been demonstrated to reduce blood pressure. Genome editing can productively target each of t...

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Literature Corpus work: b5299292-c88b-5bd4-80af-bf6c971f41f6
DOI: 10.1101/2023.05.17.541156

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