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Article

Is It Ever Wise to Edit Wild-Type Alleles? Engineered CRISPR Alleles Versus Millions of Years of Human Evolution.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2024

Kozan Darby W, Farber Steven A

Abstract excerpt

The tremendous burden of lipid metabolism diseases, coupled with recent developments in human somatic gene editing, has motivated researchers to propose population-wide somatic gene editing of PCSK9 (proprotein convertase subtilisin/kexin type 9) within the livers of otherwise healthy humans. The best-characterized molecular function of PCSK9 is its ability to regulate plasma LDL (low-density lipoprotein) levels...

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Topics

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Share to Alleles
Share to PCSK9 gene
Share to Proprotein Convertase 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, LDL

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Source

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Identifiers

PMID: 38059350
DOI: 10.1161/ATVBAHA.123.318069
PMCID: PMC10948015

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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