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Article

Insights into Resistance Mechanisms of Inhibitors to Mps1 C604Y Mutation via a Comprehensive Molecular Modeling Study.

Molecules (Basel, Switzerland) - 20 Jun 2018

Chen Yuan, Yu Wenquan, Jiang Cui-Cui, Zheng Jin-Gui

Abstract excerpt

Mono-polar spindle 1 (Mps1/TTK) represents a protein kinase reported to be vital for cell division processes and is generally regarded as an attractive target for the treatment of hepatocellular carcinoma, breast carcinoma, and colon cancer. However, the C604Y mutation has been linked to acquired resistance. Recently, three potential small-molecule inhibitors of Mps1 (i.e., reversine, NMS-P715, and its derivative...

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Identifiers

PMID: 29925769
DOI: 10.3390/molecules23061488
PMCID: PMC6100145

Genes

NMS
TTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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