Article

Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma

2024-04-27

Abstract excerpt

The sub-ventricular zone (SVZ) is the most well-characterized neurogenic area in the mammalian brain. We previously showed that in 65% of patients with glioblastoma (GBM), the SVZ is a reservoir of cancer stem-like cells that contribute to treatment resistance and emergence of recurrence. Here, we built a single-nucleus RNA-sequencing-based microenvironment landscape of the tumor mass (T_Mass) and the SVZ (T_SVZ)...

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Literature Corpus work: b4e7e82e-5058-57a8-8d72-e663072a1251
DOI: 10.1101/2024.04.24.590852

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