Article

SHP2 inhibitor PHPS1 regulates macrophage-adipocyte interaction to alleviate inflammation and adipocyte insulin resistance, via NF-κB suppression and IRS-1/GLUT-4 restoration

2025-12-24

Abstract excerpt

<title>Abstract</title> <p>This study explored the anti-inflammatory and insulin resistance-regulating effects of SHP2 inhibitor PHPS1 using a Transwell co-culture system of adipocytes and macrophages to mimic the in vivo adipose microenvironment. Two models were established: TNF-α-stimulated 3T3-L1 adipocytes (single culture) and LPS-induced insulin-resistant 3T3-L1/RAW 264.7 co-cultures. After 24 h of 10 μM PHP...

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Literature Corpus work: 11aaedf4-7851-51e9-abd9-a7da2c8e5c7d
DOI: 10.21203/rs.3.rs-8391295/v1

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