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Comparative analyses of gene expression in common marmoset and human pluripotent stem cells (PSCs) identify factors enhancing homologous recombination efficiency in the <i>HPRT</i> locus of human PSCs

2021-04-06

Abstract excerpt

A previous study assessing the efficiency of the genome editing technology CRISPR-Cas9 for knock-in gene targeting in common marmoset (marmoset; Callithrix jacchus ) embryonic stem cells (ESCs) unexpectedly identified innately enhanced homologous recombination (HR) activity in marmoset ESCs (cmESCs). Here, we compared gene expression in marmoset and human pluripotent stem cells (PSCs) using transcriptomic and qua...

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Literature Corpus work
b4d706ce-306f-5abe-878f-884ec3ae1177
DOI
10.1101/2021.04.05.438539
Open publication

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Comparative analyses of gene expression in common marmoset and human pluripotent stem cells (PSCs) identify factors enhancing homologous recombination efficiency in the <i>HPRT</i> locus of human PSCsDOI 10.1101/2021.04.05.438539
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