Modulation of DNA Damage Response by Sphingolipid Signaling: An Interplay that Shapes Cell Fate

Abstract excerpt

Although once considered as structural components of eukaryotic biological membranes, research in the past few decades hints at a major role of bioactive sphingolipids in mediating an array of physiological processes including cell survival, proliferation, inflammation, senescence, and death. A large body of evidence points to a fundamental role for the sphingolipid metabolic pathway in modulating the DNA damage...

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