Article

Single-cell analysis reveals the cellular and transcriptional diversity of thyrocytes in the normal pediatric thyroid

2025-11-17

Abstract excerpt

<h4>ABSTRACT</h4> To enhance the understanding of cellular heterogeneity within the pediatric thyroid, single-nuclei RNA sequencing was used to recover 38,069 non-pathogenic cells from thyroid tissue of three pediatric patients. The recovered cells were analyzed using the SWANS ( S ingle Entity W orkflow AN alysi S) pipeline (version 1.0). Analysis revealed seven major cell types: thyrocytes, endothelial cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4c2ee0a-12ef-5460-81c1-4db3a0d8a7b8
DOI: 10.1101/2025.11.17.687863

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell analysis reveals the cellular and transcriptional diversity of thyrocytes in the normal pediatric thyroidDOI 10.1101/2025.11.17.687863Read

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult PatientsSemantic proximity Read

A developmental cell atlas of the human thyroid glandSemantic proximity Read

Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinomaSemantic proximity Read

Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancersSemantic proximity Read

Anaplastic transformation in thyroid cancer revealed by single-cell transcriptomicsSemantic proximity Read

Tumor type and cell type-specific gene expression alterations in diverse pediatric central nervous system tumors identified using single nuclei RNA-seqSemantic proximity Read

NBAtlas: A harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumorsSemantic proximity Read

A single-cell atlas of cancer-educated ecotypes across high-risk pediatric sarcomasSemantic proximity Read

Single‐cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between gendersSemantic proximity Read

Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumorsSemantic proximity Read

Immune-parenchymal multicellular niches are shared across distinct thyroid autoimmune diseasesSemantic proximity Read

A stress-function tradeoff organizes epithelial heterogeneity across spatial scales in the human thyroidSemantic proximity Read