Article

Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancers

2024-02-19

Abstract excerpt

Sixty percent of papillary thyroid cancers (PTCs) are driven by BRAF V600E , a mutation associated with high inter- and intra-tumoral heterogeneity. PTCs may become highly aggressive anaplastic thyroid cancers (ATC). While single cell transcriptomics may resolve this heterogeneity, it is potentially confounded by technical effects whose correction may dampen inter-tumor variations. Here we profiled ATCs and BRA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 833e731e-7096-51b3-a791-5026545f7c2b
DOI: 10.1101/2024.02.15.580495

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancersDOI 10.1101/2024.02.15.580495Read

Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell ResolutionSemantic proximity Read

Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinomaSemantic proximity Read

Spatial and Single‐Cell Transcriptomics Unraveled Spatial Evolution of Papillary Thyroid CancerSemantic proximity Read

Single-Cell Transcriptomic Analysis of Ecosystems in Papillary Thyroid Carcinoma ProgressionSemantic proximity Read

Single‐cell transcriptomic landscape reveals the differences in cell differentiation and immune microenvironment of papillary thyroid carcinoma between gendersSemantic proximity Read

Mutation-specific dynamics of dedifferentiation trajectories and tumor-stromal interactions in thyroid cancer.Semantic proximity Read

Integrated analysis of tumor microenvironment features to establish a diagnostic model for papillary thyroid cancer by using bulk and single-cell RNA sequencing technologySemantic proximity Read

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult PatientsSemantic proximity Read

Papillary Thyroid Cancer Remodels the Genomic Fabrics of DNA Replication, Repair and TranscriptionSemantic proximity Read

An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulationsSemantic proximity Read

Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability.Semantic proximity Read

Spatial Transcriptomics in Thyroid Cancer: A PRISMA-Guided Systematic Review of Platforms, Applications, and Tumor MicroenvironmentSemantic proximity Read