Article

Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies

2025-05-06

Abstract excerpt

Recipients of allogeneic transplants or patients with autoimmune disease require immune suppression, often with calcineurin inhibitors. There is an expanding repertoire of immune effector cell therapies, including CD19 CAR-T cells and viral-specific T cells, deployed in these patients; however, ongoing calcineurin inhibition may be detrimental to cell therapy function. We developed a CRISPR/Cas9-based approach to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b4ba2928-2923-5d44-b810-6e63900ab1eb
DOI: 10.1101/2025.04.30.651441

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular TherapiesDOI 10.1101/2025.04.30.651441Read

CRISPR screens establish regulatory maps of immunosuppressive surface molecules in cancerSemantic proximity Read

In vivo CRISPR screens identify key modifiers of CAR T cell function in myelomaSemantic proximity Read

Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemiaSemantic proximity Read

Cytosine base editing enables quadruple-edited allogeneic CART cells for T-ALLSemantic proximity Read

Multiplex Cripsr/Cas9 Genome Editing to Generate Potent Universal CART and PD1-Deficient Cells Against LeukemiaSemantic proximity Read

SynAuto-X: A Programmable CRISPR-dCas9 Circuit for Precision Inflammation Control in Autoimmune DisordersSemantic proximity Read

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacySemantic proximity Read

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapySemantic proximity Read

Engineering of Primary Human B cells with CRISPR/Cas9 Targeted NucleaseSemantic proximity Read

Reprogramming the antigen specificity of B cells using genomeediting technologiesSemantic proximity Read

CRISPR-based screens uncover determinants of immunotherapy response in multiple myelomaSemantic proximity Read

CRISPR-based screens uncover determinants of immunotherapy response in Multiple MyelomaSemantic proximity Read