Article

<i>ERBB2</i> and <i>KRAS</i> Alterations Mediate Response to EGFR Inhibitors in early stage Gallbladder Cancer

2018-03-28

Abstract excerpt

The uncommonness of gallbladder cancer has contributed to the generally poor understanding of the disease, with scant reports restricted to advance-stage tumors. Here, using an integrated analysis of whole exome and phospho-proteome, we show recurrent activating ERBB2 and KRAS somatic mutations are present in 6 and 3 of 44 early-stage rare gallbladder tumors, respectively. In vitro and in vivo cell-based and b...

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Literature Corpus work: b4a2030f-9224-5387-96d2-872eab1d6984
DOI: 10.1101/290486

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