Article

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

2022-10-07

Abstract excerpt

HIV disease remains prevalent in the USA and chronic kidney disease remains a major cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a sensor for viral dsRNA, including HIV-1. We show that PKR inhibition by compound C16 ameliorates the HIV-associated nephropathy (HIVAN) kidney phenotype in the Tg26 transgenic mouse model, with reversal of mitochondri...

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Literature Corpus work: b47ac3a2-a04d-5708-96f3-893ad985eb63
DOI: 10.1101/2022.10.03.510678

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