Article

HIV viral protein R induces loss of DCT1-type renal tubules

2023-02-03

Abstract excerpt

Hyponatremia and salt wasting is a common occurance in patients with HIV/AIDS, however, the understanding of its contributing factors is limited. HIV viral protein R (Vpr) contributes to HIV-associated nephropathy. To investigate the effects of Vpr on the expression level of the Slc12a3 gene, encoding the Na-Cl cotransporter, which is responsible for sodium reabsorption in distal nephron segments, we performed si...

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Literature Corpus work: 4f237ca6-d72b-5cf7-91e0-ed1f0fa5a2bf
DOI: 10.1101/2023.02.02.526686

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