Article

SNP-ChIP: A versatile and tag-free method to quantify changes in protein binding across the genome

2018-08-10

Abstract excerpt

Chromatin-immunoprecipitation followed by sequencing (ChIP-seq) is the method of choice for mapping genome-wide binding of chromatin-associated factors. However, broadly applicable methods for between-sample comparisons are lacking. Here, we introduce SNP-ChIP, a method that leverages small-scale intra-species polymorphisms, mainly SNPs, for quantitative spike-in normalization of ChIP-seq results. Sourcing spike-i...

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Literature Corpus work: b470c3aa-0fe3-55bc-a1df-1434ea351b37
DOI: 10.1101/390005

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