Article

GNOMES: an integrated framework for genome-wide normalization and differential binding analysis of CUT&RUN and ChIP-seq data

2026-04-21

Abstract excerpt

<h4>Background</h4> Despite their use, quantitative comparison of epigenomic datasets such as ChIP-seq and CUT&RUN remains challenging, particularly due to difficulties in signal normalization across samples and conditions. Normalization solely based on sequencing depth is often insufficient due to the high variability in signal-to-noise ratios across samples, even from a same experiment. While exogeneous spike-i...

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Literature Corpus work: d095ce17-8272-5589-80f2-69207befe226
DOI: 10.64898/2026.04.16.718722

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