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Article

PTEN mutations in autism spectrum disorder and congenital hydrocephalus: developmental pleiotropy and therapeutic targets.

Trends in neurosciences - 1 Dec 2021

DeSpenza Tyrone, Carlson Marina, Panchagnula Shreyas, Robert Stephanie, Duy Phan Q, Mermin-Bunnell Nell, Reeves Benjamin C, Kundishora Adam, Elsamadicy Aladine A, Smith Hannah, Ocken Jack, Alper Seth L, Jin Sheng Chih, Hoffman Ellen J, Kahle Kristopher T

Abstract excerpt

The lack of effective treatments for autism spectrum disorder (ASD) and congenital hydrocephalus (CH) reflects the limited understanding of the biology underlying these common neurodevelopmental disorders. Although ASD and CH have been extensively studied as independent entities, recent human genomic and preclinical animal studies have uncovered shared molecular pathophysiology. Here, we review and discuss...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34625286
DOI: 10.1016/j.tins.2021.08.007
PMCID: PMC8692171

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