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Article

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

2 Jan 2013

Abstract excerpt

Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, such as Crohn's disease and colorectal cancer. Here, we show that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice. Loss of either Nod2 or RIP2 resulted in a proinflammatory microenvironment that...

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PMID: 23281400
DOI: 10.1172/jci62236

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