Article

<i>De novo</i> mutations mediate phenotypic switching in an opportunistic human lung pathogen

2024-02-06

Abstract excerpt

Bacteria evolving within human hosts encounter selective tradeoffs that render mutations adaptive in one context and deleterious in another. Here, we report that the cystic fibrosis-associated pathogen Burkholderia dolosa overcomes in-human selective tradeoffs by acquiring successive point mutations that alternate phenotypes. We sequenced the whole genomes of 931 respiratory isolates from two recently infected pa...

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Literature Corpus work: b3d57ca5-19f0-5497-b53a-81bc3617e994
DOI: 10.1101/2024.02.06.579193

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