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Article

Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs.

Genome research - 1 Apr 2017

Lee Amy Huei-Yi, Flibotte Stephane, Sinha Sunita, Paiero Adrianna, Ehrlich Rachel L, Balashov Sergey, Ehrlich Garth D, Zlosnik James E A, Mell Joshua Chang, Nislow Corey

Abstract excerpt

Chronic bacterial infections of the lung are the leading cause of morbidity and mortality in cystic fibrosis patients. Tracking bacterial evolution during chronic infections can provide insights into how host selection pressures-including immune responses and therapeutic interventions-shape bacterial genomes. We carried out genomic and phenotypic analyses of 215 serially collected Burkholderia cenocepacia...

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Identifiers

PMID: 28325850
DOI: 10.1101/gr.213363.116
PMCID: PMC5378182

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