Article
Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes.
Nature genetics - 13 Nov 2011
Lieberman Tami D, Michel Jean-Baptiste, Aingaran Mythili, Potter-Bynoe Gail, Roux Damien, Davis Michael R, Skurnik David, Leiby Nicholas, LiPuma John J, Goldberg Joanna B, McAdam Alexander J, Priebe Gregory P, Kishony Roy
Abstract excerpt
Bacterial pathogens evolve during the infection of their human host(1-8), but separating adaptive and neutral mutations remains challenging(9-11). Here we identify bacterial genes under adaptive evolution by tracking recurrent patterns of mutations in the same pathogenic strain during the infection of multiple individuals. We conducted a retrospective study of a Burkholderia dolosa outbreak among subjects with...
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