Article

Robust prediction of patient outcomes with immune checkpoint blockade therapy for cancer using common clinical, pathologic, and genomic features

2023-07-05

Abstract excerpt

Despite the revolutionary impact of immune checkpoint blockade (ICB) in cancer treatment, accurately predicting patients’ responses remains elusive. We analyzed eight cohorts of 2881 ICB-treated patients across 18 solid tumor types, the largest dataset to date, examining diverse clinical, pathologic, and genomic features. We developed the LOgistic Regression-based Immunotherapy-response Score (LORIS) using a trans...

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Literature Corpus work: 8f4d3330-d4d6-523e-b2b7-33e450582f0b
DOI: 10.1101/2023.07.04.547697

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