Article

Somatic variants activating the RAS-MAPK pathway confer susceptibility to hippocampal sclerosis in drug-resistant epilepsy

2026-04-08

Abstract excerpt

Hippocampal sclerosis is a frequent finding in pediatric epilepsy surgery and has traditionally been regarded as an acquired lesion. It commonly co-occurs with focal cortical dysplasia (FCD IIIa), yet whether hippocampal injury is secondary to seizures or reflects a shared underlying etiology remains unresolved. Here we identified somatic variants activating the RAS–MAPK pathway in 40% of patients with hippocampal...

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Literature Corpus work: b364ec5c-a1a6-564d-88a0-c713856b706b
DOI: 10.64898/2026.04.06.716727

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