Article

Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy

2026-01-27

Abstract excerpt

Mesial ( a.k.a., medial) temporal lobe epilepsy (MTLE) is the most common focal epilepsy 1,2 and, in drug-resistant cases, is treated by surgical removal of the anterior temporal lobe, which often shows neuronal loss and gliosis consistent with hippocampal sclerosis (HS) 2 . MTLE with HS has minimal contribution from germline genetic variation 3 , and is associated with prior precipitating insults such as prol...

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Literature Corpus work: 2a48c284-56d1-5dc4-8469-e5f873eef28d
DOI: 10.64898/2026.01.26.701822

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