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Article

RAS pathway: The new frontier of brain mosaicism in epilepsy.

Neurobiology of disease - 1 May 2023

Sran Sahibjot, Bedrosian Tracy A

Abstract excerpt

As cells divide during development, errors in DNA replication and repair lead to somatic mosaicism - a phenomenon in which different cell lineages harbor unique constellations of genetic variants. Over the past decade, somatic variants that disrupt mTOR signaling, protein glycosylation, and other functions during brain development have been linked to cortical malformations and focal epilepsy. More recently,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36907520
DOI: 10.1016/j.nbd.2023.106074
PMCID: PMC13463200

Genes

BRAF
KRAS
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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