Article

Multi-level systems analysis identifies XPO1 as a druggable target linked to NFκB activation, proliferation, tumor clonality and long-term survival in Adult T-cell Leukemia

2025-10-21

Abstract excerpt

<title>Abstract</title> <p> Adult T-cell leukemia (ATL), an aggressive malignancy triggered by human T-cell leukemia virus-1 (HTLV-1), has a dismal prognosis and limited therapeutic options. Here, we investigate the nuclear export protein XPO1 as a critical driver of ATL proliferation and a promising therapeutic target. We used a multi-level approach, combining systems biology analysis of three independent ATL p...

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Literature Corpus work: b35f0291-3c47-56e3-9da9-4f43a89c4098
DOI: 10.21203/rs.3.rs-7879396/v1

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Multi-level systems analysis identifies XPO1 as a druggable target linked to NFκB activation, proliferation, tumor clonality and long-term survival in Adult T-cell LeukemiaDOI 10.21203/rs.3.rs-7879396/v1Read

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