Article

Improved genome inference in the MHC using a population reference graph

2014-07-08

Abstract excerpt

In humans and many other species, while much is known about the extent and structure of genetic variation, such information is typically not used in assembling novel genomes. Rather, a single reference is used against which to map reads, which can lead to poor characterisation of regions of high sequence or structural diversity. Here, we introduce a population reference graph, which combines multiple reference seq...

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Identifiers and source

Literature Corpus work: b33a28d3-a336-5c0e-aa5f-637413219688
DOI: 10.1101/006973

Open publication

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