Article
Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria
2017-09-25
Abstract excerpt
The pathogenesis of severe Plasmodium falciparum malaria is incompletely understood. Since the pathogenic stage of the parasite is restricted to blood, dual RNA-sequencing of host and parasite transcripts in blood can reveal their interactions at a systemic scale. Here we identify human and parasite gene expression associated with severe disease features in Gambian children. Differences in parasite load explained...
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Identifiers and source
- Literature Corpus work
- b32cefd3-3576-5ee8-89a6-3d4a84f073b7
- DOI
- 10.1101/193631